Justin Timberlake, who dominated the MTV Europe Music Awards in 2006, could do it again this year with four nominations for the event taking place in Munich on November 1.
His closest rivals, with three nominations each after an online poll, are Amy Winehouse, Avril Lavigne, Beyonce, Fall Out Boy, Linkin Park, My Chemical Romance, Nelly Furtado and Rihanna.
Timberlake was named best male and best pop act in Copenhagen last year and hosted the ceremony, one of pop music's biggest events outside the United States.
With MTV handing control of most of the awards to online voters, the heart-throb has been shortlisted this year for Video Star Award for "What Goes Around," Headliner Award after a world tour, Ultimate Urban Act and Solo Artist of 2007.
In the coveted Solo Artist category he is up against Canada's Furtado and Lavigne, Barbados-born Rihanna, U.S. star Christina Aguilera and Lebanon-born Mika.
Linkin Park, My Chemical Romance, Fall Out Boy, Good Charlotte and Tokio Hotel fight it out for the Band of 2007 award while Album of the Year pits Akon against Winehouse, Lavigne, Linkin Park and Furtado.
Lavigne, My Chemical Romance, Mika and the Foo Fighters are expected to perform at the OlympiaHalle, while U.S. hip-hop star Snoop Dogg will host.