Jennifer Lopez and singer Marc Anthony arrive at the Ciampino airport in Rome November 16, 2006.
"We are very excited for Tom and Katie," Martin Holmes, the bride's father, told Sky Italia television on arrival at the airport.
His wife Kathleen declined to give any details about her 27-year-old daughter's wedding dress, which has been designed by Giorgio Armani.
Actress Brooke Shields, who had a public spat with 44-year-old Cruise last year after he criticized her for taking medication to treat post-natal depression, also arrived in Rome on Thursday for the wedding.
Cruise and Holmes, stalked by paparazzi who are besieging their hotel in central Rome, made their first public appearance in the city late on Wednesday, when they sneaked out with their baby daughter Suri to attend a dinner with the mayor of Rome.