MTV set up a green carpet at the Palacio de los Deportes dome, in southern Mexico City, where artists and guests paraded before screaming fans while television crews and photographers elbowed for room.
Clad in their trademark white bunny outfits to keep their identities a secret, members of the Mexican band Austin TV joked with fans.
Mexican band Mana won video of the year and best rock artist plus a special award to honor their two decades in the music business.
Mana's drummer Alex Gonzalez told Reuters the band was getting ready for a tour that will take it across Latin America and Europe.