The Rockets didn't have an answer for the 7-foot-1 Frenchman on either end of the floor. He had a double-double in the first quarter and 18 rebounds at halftime.
Teammate Gordon Hayward finished with 29 points, seven assists and four rebounds. Rookie Rodney Hood put up a career high for the second consecutive game with 20 points.
Corey Brewer led the Rockets with 25 points, and James Harden had 15.
Washington's John Wall had 21 points, seven rebounds and six assists to lead the Wizards past short-handed Memphis 107-87.
Memphis sat three starters: the injured Mike Conley, and Marc Gasol and Zach Randolph, who were resting on the second night of a back-to-back. The Grizzlies also held out key reserve Tony Allen.
Indiana won for the ninth time in their last 10 games, beating Milwaukee 109-103 in overtime to pull within 3 1/2 games of the Bucks for the sixth seed in the Eastern Conference.
Rodney Stuckey scored 25 points and Luis Scola had 17 points and 15 rebounds for the Pacers.
In Los Angeles, the New York Knicks ended their five-game losing streak with just their fifth road victory of the season, topping the Lakers 101-94.
Tim Hardaway Jr. scored 22 points and Alexey Shved had 14 points and 11 rebounds for the Knicks.